Lactobacillus plantarum DR7 -
Improves Alzheimer’s Disease
AD is one of the most detrimental brain diseases and is most prevalent in the aging and aged populations. One of the primary culprits is the formation of protein plaque in the brain. Fruit fries (Drosophila melanogaster) is a good model to study AD, where mutants of fruit fries with AD have been developed.
Normal fruit fries without AD have perfect eye structures:
• Hexagonal and neatly arranged ommatidias
• Straight and neatly arranged bristles
Mutant fruit fries with AD have malformed eye structures:
• Lost of hexagonal shapes in ommatidias
• Ommatidias are no longer neatly arranged
• Bristles are broken and no longer neatly arranged
• Formation of holes on ommatidias
Lactobacillus plantarum DR7 improved eye structures(n=20) of mutant fruit fies with AD :
• Almost perfect ommatidias
• Almost perfect bristles
• Rare formation of holes
References:
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Chong, H.X., Yusoff, N.A.A., Hor, Y.Y., Lew, L.C., Jaafar, M.H., Choi, S.B., Yusoff, M.S.B., Wahid, N., Abdullah, M.F.I.L., Zakaria, N. and Ong, K.L., (2019). Lactobacillus plantarum DR7 alleviates stress and anxiety in adults: a randomised, double-blind, placebo-controlled study. Beneficial microbes, 1-20.
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Chong, H.X., Yusoff, N.A.A., Hor, Y.Y., Lew, L.C., Jaafar, M.H., Choi, S.B., Yusoff, M.S., Wahid, N., Abdullah, M.F.I., Zakaria, N. and Ong, K.L., (2019). Lactobacillus plantarum DR7 improved upper respiratory tract infections via enhancing immune and inflammatory parameters: A randomized, double-blind, placebo-controlled study. Journal of dairy science.
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Lew, L. C., Choi, S. B., Khoo, B. Y., Sreenivasan, S., Ong, K. L., & Liong, M. T. (2018). Lactobacillus plantarum DR7 Reduces Cholesterol via Phosphorylation of AMPK That Down-regulated the mRNA Expression of HMG-CoA Reductase. Korean journal for food science of animal resources, 38(2), 350.